Rome, Italy, October 11-14, 2023

Poster Session 1

THURSDAY, OCTOBER 12, 2023


14:15-15:15 Poster Session 1
Session Chairs:
Jennifer Pollock, University of Alabama, Birmingham, USA
Michelle Gumz, University of Florida, Gainesville, USA

ET-1 INDUCED SIGNALING PATHWAY IN UROTHELIAL CARCINOMA
Enno Storz
University Hospital Cologne, Department of Urology, Cologne, Germany

EBV INDUCED AND ET-1 DEPENDENT REGULATION OF SEMINOMA
Enno Storz
University Hospital Cologne, Department of Urology, Cologne, Germany

THE ENDOTHELIN-1-DRIVEN FEED-FORWARD LOOPS BETWEEN HIGH-GRADE SEROUS OVARIAN CANCER CELLS AND TUMOR MICROENVIRONMENT REGULATES THERAPEUTIC RESPONSE
Piera Tocci
Preclinical Models and New Therapeutic Agents Unit, IRCCS, Regina Elena National
Cancer Institute, Rome, Italy

THE CORRELATION OF VIMENTIN3 AND TOLL-LIKE RECEPTOR 4 IN PROSTATE CANCER CELL LINES
Melanie von Brandenstein
University Hospital of Cologne, Institute of Urology, Cologne, Germany

ET-1 INDUCED REGULATION OF MIR-371A-3P IN PROSTATE CANCER CELLS
Melanie von Brandenstein
University Hospital of Cologne, Institute of Urology, Cologne, Germany

THE BETA-ARRESTIN1/ENDOTHELIN AXIS BOLSTERS A CAF-DEPENDENT INVADOSOME ACTIVITY AND OVARIAN
CANCER METASTATIC POTENTIAL
Danila Del Rio
Institute of Molecular Biology and Pathology-CNR, Rome, Italy

COMPARISON OF THE ENDOTHELIN-A AND -B RECEPTORS EXPRESSION IN DIFFERENT MURINE TUMOR MODELS BY SIMULTANEOUS FLUORESCENCE IMAGING
JULIETTE DELAHAYE
Juliette Delahaye
Clinic for Radiology, University Hospital Münster, Münster, Germany

ROLE OF THE ENDOTHELIN SIGNALING PATHWAY IN DIFFUSE IDH1-MUTANT LOW-GRADE AND HIGH-GRADE GLIOMAS CELL PROLIFERATION AND FATE
Donovan Pineau
Institut de génomique fonctionnelle (IGF), Montpellier, France

PARP INHIBITOR BOOTS THE TRANSCRIPTION OF ENDOTHELIN A RECEPTOR IN HIGH-GRADE SEROUS OVARIAN CANCERS
Celia Roman
Preclinical Models and New Therapeutic Agents Unit, IRCCS, Regina Elena National Cancer Institute, Rome, Italy

HE ENDOTHELIN-1/ MIR-200B-C/ZEB1 CIRCUIT DRIVES NOVEL GASDERMIN E NUCLEAR FUNCTIONS TO FUEL INFLAMMATORY RESPONSES AND METASTATIC PROGRESSION IN HIGH-GRADE SEROUS OVARIAN CANCER
Rosanna Sestito
Preclinical Models and New Therapeutic Agents Unit, IRCCS, Regina Elena National Cancer Institute, Rome, Italy

NONSELECTIVE BLOCKADE OF ENDOTHELIN RECEPTORS AND OTHER NOVEL THERAPEUTIC STRATEGIES FOR RESISTANT HYPERTENSION
Alessia Valentini
University of Tor Vergata - Department of Systems Medicine, Rome, Italy

SAFETY AND EFFICACY OF NEW DUAL ENDOTHELIN RECEPTOR ANTAGONIST APROCITENTAN IN RESISTANT HYPERTENSION: A SYSTEMATIC REVIEW AND META-ANALYSIS
Bambang Widyantoro
Department of Cardiology and Vascular Medicine, Universitas Indonesia - National Cardiovascular Center Harapan Kita, Jakarta, Indonesia

SOVATELTIDE PROMOTES NEURAL REGENERATION AND IMPROVES MITOCHONDRIA FUNCTION IN A NEONATAL RAT MODEL OF HYPOXIC-ISCHEMIC ENCEPHALOPATHY
Seema Briyal
College of Pharmacy, Midwestern University, Downers Grove, IL, USA

ENDOTHELIN-1 (ET-1) MEDIATES BRAIN PERICYTE SENESCENCE IN DIABETES-MIMICKING CONDITIONS: RELEVANCE TO DEMENTIA
Mia Edgerton-Fulton
Medical University of South Carolina-Department of Pathology and Laboratory Medicine, Charleston, USA

OTOPROTECTIVE EFFICACY OF SOVATELTIDE AGAINST NOISE OR AMINOGLYCOSIDE-INDUCED HEARING LOSS
Kartike Gulati
Indiana Ear and Sinus Institute, Highland, USA

RESULTS OF A RANDOMIZED, MULTICENTER TRIAL TO DETERMINE THE EFFICACY OF SOVATELTIDE IN TREATING
Anil Gulati
Pharmazz Inc, Willowbrook, USA

ENDOTHELIN-1 CAN MEDIATE TAU PATHOLOGY AND INCREASE OLIGOMERIC TAU PHOSPHORYLATION (THR-231) IN BRAIN MICROVASCULAR ENDOTHELIAL CELLS (BMVECS)
Eda Karakaya
Department of Pathology and Laboratory Medicine, Medical Unversity of South Carolina, Charleston, USA

TISSUE ENDOTHELIN-1 (ET-1) LEVELS CORRELATE WITH THE DEGREE OF HYPOXIA AND COGNITIVE DECLINE IN DIABETES IN A RAT MICROEMBOLI (ME) MODEL OF VASCULAR COGNITIVE IMPAIRMENT/DEMENTIA (VCID)
Weiguo Li
Department of Pathology and Laboratory Medicine, College of Medicine, Medical University of South Carolina, Charleston, USA

PHARMACOLOGY MATTERS: VALIDATION AND PREDICTION OF IN VIVO RECEPTOR SELECTIVITY OF ENDOTHELIN ANTAGONISTS AT CLINICALLY RELEVANT DOSES IN PATIENTS
Janet Maguire
University of Cambridge, Experimental Medicine and Immunotherapeutics, Cambridge, UK

EVALUATION OF ET-2 PHYSIOLOGY IN THE LUNG VIA THE GENERATION OF A NOVEL EDN-2 LUMINESCENT REPORTER MICE
GUSTY RIZKY TEGUH RYANTO
Gusty Rizky Teguh Ryanto
Laboratory of Clinical Pharmaceutical Science, Kobe Pharmaceutical University, Kobe, Japan

ENDOTHELIN-2 SPECIFICALLY EXPRESSED PNEUMOLOGY IN THE PULMONARY NEUROENDOCRINE CELLS PLAYS A NOVEL AND CRUCIAL ROLE IN THE DEVELOPMENT OF HYPOXIA-INDUCED PULMONARY HYPERTENSION
Yoko Susuki
Laboratory of Clinical Pharmaceutical Science, KobePharmaceuticalUniversity,Kobe, Japan

ALTERATIONS IN THE CARDIAC AND RENAL ENDOTHELIN SYSTEM IS ASSOCIATED WITH CARDIAC DYSFUNCTION IN A PRECLINICAL MODEL OF LUPUS
Justin van Beusecum
Medical University of South Carolina, Division of Nephrology, Department of Medicine, Charleston, USA